2014 / 2015 / 2016 / 2017 / 2018 / 2019 / 2020
2021
Viitanen R, Moisio OA, Lankinen P, Li XG, Koivumäki M, Suilamo S, Tolvanen T, Taimen K, Mali M, Kohonen I, Koskivirta I, Oikonen V, Virtanen H, Santalahti K, Autio A, Saraste A, Pirilä L, Nuutila P, Knuuti J, Jalkanen S, Roivainen A. First-in-Human Study of 68Ga-DOTA-Siglec-9, PET Ligand Targeting Vascular Adhesion Protein 1. Journal of Nuclear Medicine. 62:577-583, 2021. Feature article of the month.
Eichin D, Pessia A, Takeda A, Laakkonen J, Bellmann L, Kankainen M, Imhof BA, Stoitzner P, Tang J, Salmi M, Jalkanen S. CD73 contributes to anti-inflammatory properties of afferent lymphatic endothelial cells in humans and mice. European Journal of Immunology. Jan;51(1):231-246, 2021.
Tadayon S, Dunkel J, Takeda A, Eichin D, Virtakoivu R, Elima K, Jalkanen S*, Hollmén M*. Lymphatic Endothelial Cell Activation and Dendritic Cell Transmigration Is Modified by Genetic Deletion of Clever-1. Frontiers in Immunology. Mar 4;12:602122, eCollection 2021. .*equal contribution
Cao Y, Yang J, Eichin D, Zhao F, Qi D, Kähäri L, Jia C, Peurla M, Rosenholm JM, Zhao Z, Jalkanen S, Li J. Self-Synthesizing Nanorods from Dynamic Combinatorial Libraries against Drug Resistant Cancer. Angewandte Chemie. Feb 8;60(6):3062-3070, 2021.
Spicer A, Jalkanen S. Why Haven’t We Found an Effective Treatment for COVID-19? Frontiers in Immunology. doi: 10.3389/fimmu.2021.644850, 31 March 2021.
2020
Jalkanen J, Hollmén M, Jalkanen S. Interferon beta-1a for COVID-19: critical importance of the administration route. Critical Care. 12;24(1):335, 2020. (commentary)
Hollmén M, Figueiredo R, Jalkanen S. New tools to prevent cancer growth and spread: a ‘Clever’ approach. British Journal of Cancer. 123(4):501-509, 2020
Fair-Mäkelä R, Ugur M, Iftakhar-E-Khuda I, Kähäri L, Kukkonen-Macchi A, Brenyah HM, Miyasaka M, Pabst O, Jalkanen S. Robo4 Contributes to the Turnover of Peyer’s Patch B Cells. Mucosal Immunology. 13:245-256, 2020.
Jalkanen J, Pettilä V, Huttunen T, Hollmen M, Jalkanen S. Glucocorticoids Inhibit Type I IFN Beta Signaling and the Upregulation of CD73 in Human Lung. Intensive Care Medicine. 46(10):1937-1940.2020.
Ranieri VM, Pettilä V, Karvonen MK, Jalkanen J, Nightingale P, Brealey D, Mancebo J, Ferrer R, Mercat A, Patroniti N, Quintel M, Vincent JL, Okkonen M, Meziani F, Bellani G, MacCallum N, Creteur J, Kluge S, Artigas-Raventos A, Maksimow M, Piippo I, Elima K, Jalkanen S, Jalkanen M, Bellingan G; INTEREST Study Group. Effect of Intravenous Interferon β-1a on Death and Days Free From Mechanical Ventilation Among Patients With Moderate to Severe Acute Respiratory Distress Syndrome: A Randomized Clinical Trial. Journal of the American Medical Association. 25;323(8):725-733, 2020.
Jalkanen S, Salmi M. Lymphatic endothelial cells of the lymph node. Nature Reviews Immunology. 20(9):566-578, 2020.
2019
Salmi M, Jalkanen S. Vascular Adhesion Protein-1: a cell surface amine oxidase in translation. Antioxid Redox Signal. 2019.
Losenkova K, Paul M, Irjala H, Jalkanen S, Yegutkin GG. Histochemical Approach for Simultaneous Detection of Ectonucleotidase and Alkaline Phosphatase Activities in Tissues. Methods in Molecular Biology . 2020;2041:107-116. doi: 10.1007/978-1-4939-9717-6_7.
Koivisto MK, Tervahartiala M, Kenessey I, Jalkanen S, Boström PJ, Salmi M. Cell-type-specific CD73 expression is an independent prognostic factor in bladder cancer. Carcinogenesis. 40:84-92, 2019.
Zeiner J, Loukovaara S, Losenkova K, Zuccarini M, Korhonen AM, Lehti K, Kauppinen A, Kaarniranta K, Müller CE, Jalkanen S, Yegutkin GG. Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage. Journal of Molecular Medicine. 97:341-354, 2019.
Siitonen R, Peuhu E, Autio AK, Liljenbäck H, Mattila E, Metsälä O, Käkelä M, Saanijoki T, Dijkgraaf I, Jalkanen S, Ivaska J, Roivainen A. 68Ga-DOTA-E[c(RGDfK)]2 Positron Emission Tomography Imaging of SHARPIN-Regulated Integrin Activity in Mice. The Journal of Nuclear Medicine. 60(10):1380-1387, 2019.
Viitala MK, Virtakoivu R, Tadayon S, Rannikko J, Jalkanen S, Hollmén M. Immunotherapeutic Blockade of Macrophage Clever-1 Reactivates the CD8+ T Cell Response Against Immunosuppressive Tumors. Clinical Cancer Research. 1;25(11):3289-3303, 2019.
Tadayon S, Dunkel J, Takeda A, Halle O, Karikoski M, Gerke H, Rantakari P, Virtakoivu R, Pabst O, Salmi M, Hollmén M, Jalkanen S. Clever-1 contributes to lymphocyte entry into the spleen via the red pulp. Science Immunology. 29;4(33):eaat0297, 2019.
Takeda A, Hollmén M, Dermadi D, Pan J, Brulois KF, Kaukonen R, Lönnberg T, Boström P, Koskivuo I, Irjala H, Miyasaka M, Salmi M, Butcher EC, Jalkanen S. Single-cell survey of human lymphatics unveils unexpected heterogeneity and mechanisms of homing for neutrophils. Immunity. 2019 (in press)
2018
Hagert C, Sareila O, Kelkka T, Nandakumar KS, Collin M, Xu B, Guérard S, Bäcklund J, Jalkanen S, Holmdahl R. Chronic active arthritis driven by macrophages without involvement of T cells: A novel experimental model of rheumatoid arthritis. Arthritis & Rheumatology. 70:1343-1353, 2018.
Hagert C, Sareila O, Kelkka T, Jalkanen S, Holmdahl R. The macrophage mannose receptor regulates mannan-induced psoriasis, psoriatic arthritis, and rheumatoid arthritis-like disease models. Frontiers in Immunology. 9:114, 2018.
Dunkel J, Viitala M, Karikoski M, Rantakari P, Virtakoivu R, Elima K, Hollmén M, Jalkanen S, Salmi M. Enhanced antibody production in Clever-1/Syabilin-1 deficient mice. Frontiers in Immunology. 9:2257, 2018.
Elo P, Tadayon S, Liljenbäck H, Teuho J, Käkelä M, Koskensalo K, Saunavaara V, Virta J, Veres TZ, Kiviniemi A, Saraste A, Marjamäki P, Airas L, Jalkanen S, Roivainen A. Vascular adhesion protein-1 is actively involved in the development of inflammatory lesions in rat models of multiple sclerosis. Journal of Neuroinflammation. 15:128, 2018.
2017
Loukovaara S, Sandholm J, Aalto K, Liukkonen J, Jalkanen S, Yegutkin GG. Deregulation of ocular nucleotide homeostasis in patients with diabetic retinopathy. Journal of Molecular Medicine. 95:193-204, 2017.
Patten DA, Wilson GK, Bailey D, Shaw RK, Jalkanen S, Salmi M, Rot A, Weston CJ, Adams DH, Shetty S. Human liver sinusoidal endothelial cells promote intracellular crawling of lymphocytes during recruitment: a new step in migration. Hepatology. 65:294-309, 2017.
Munukka E, Rintala A, Toivonen R, Nylund M, Yang B, Takanen A, Hänninen A, Vuopio J, Huovinen P, Jalkanen S, Pekkala S. Faecalibacterium prausnitzii treatment improves hepatic health and reduces adipose tissue inflammation in high-fat fed mice. ISME J 11:1667-1679, 2017.
Marttila-Ichihara F, Elima K, Auvinen K, Veres TZ, Rantakari P, Weston C, Miyasaka M, Adams D, Jalkanen S, Salmi M. Amine oxidase activity regulates the development of pulmonary fibrosis. The FASEB Journal. 31:2477-2491, 2017
Ahola-Olli AV, Würtz P, Havulinna AS, Aalto K, Pitkänen N, Lehtimäki T, Kähönen M, Lyytikäinen LP, Raitoharju E, Seppälä I, Sarin AP, Ripatti S, Palotie A, Perola M, Viikari JS, Jalkanen S, Maksimow M, Salomaa V, Salmi M, Kettunen J, Raitakari OT. Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors. American Journal of Human Genetics. 100:40-50, 2017.
Veres TZ, Kopcsányi T, van Panhuys N, Gerner MY, Liu Z, Rantakari P, Dunkel J, Miyasaka M, Salmi M, Jalkanen S, Germain RN. Allergen-Induced CD4+ T Cell Cytokine Production within Airway Mucosal Dendritic Cell-T Cell Clusters Drives the Local Recruitment of Myeloid Effector Cells. Journal of Immunology. 198:895-907, 2017.
Veres TZ, Kopcsányi T, Tirri M, Braun A, Miyasaka M, Germain RN, Jalkanen S, Salmi M. Intubation-free in vivo imaging of the tracheal mucosa using two-photon microscopy. Scientific Reports. 7:694.
Santalahti K, Havulinna A, Maksimow M. Zeller T, Blankenberg S, Vehtari A, Joensuu H, Jalkanen S, Salomaa V, Salmi M. Plasma levels of hepatocyte growth factor and placental growth factor predict mortality in a general population: a prospective cohort study. Journal of Internal Medicine. 282: 340-352, 2017.
Tervahartiala M, Taimen P, Mirtti T, Koskinen I, Ecke T, Jalkanen S, Boström PJ. Immunological tumor status may predict response to neoadjuvant chemotherapy and outcome after radical cystectomy in bladder cancer. Scientific Reports. 7:12682, 2017.
2016
Wang Q, Würtz P, Auro K, Mäkinen VP, Kangas AJ, Soininen P, Tiainen M, Tynkkynen T, Jokelainen J, Santalahti K, Salmi M, Blankenberg S, Zeller T, Viikari J, Kähönen M, Lehtimäki T, Salomaa V, Perola M, Jalkanen S, Järvelin MR, Raitakari OT, Kettunen J, Lawlor DA, Ala-Korpela M. Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence. BMC Medicine. 14:205, 2016.
Palani S, Elima K , Ekholm E, Jalkanen S, Salmi M. Monocyte stabilin-1 suppresses the activation of Th1 lymphocytes. Journal of Immunology. 196:115-123, 2016.
Takeda A, Hossain MS, Rantakari P, Simmons S, Sasaki N, Salmi M, Jalkanen S, Miyasaka M. Thymocytes in Lyve1-CRE/S1pr1f/f Mice Accumulate in the Thymus due to Cell-Intrinsic Loss of Sphingosine-1-Phosphate Receptor Expression. Frontiers in Immunology. 7:489. eCollection 2016.
Silvola JM, Virtanen H, Siitonen R, Hellberg S, Liljenbäck H, Metsälä O, Ståhle M, Saanijoki T, Käkelä M, Hakovirta H, Ylä-Herttuala S, Saukko P, Jauhiainen M, Veres TZ, Jalkanen S, Knuuti J. Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally activein atherosclerotic plaques. Scientific Reports. Oct 12;6:35089.
Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K, Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, Umemoto E. Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility. Elife 5. pii: e10561. doi: 10.7554/eLife.10561, 2016.
Rantakari P, Patten DA, Valtonen J, Karikoski M, Gerke H, Dawes H, Laurila J, Ohlmeier S, Elima K, Hübscher SG, Weston CJ, Jalkanen S, Adams DH, Salmi M, Shetty S. Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury. PNAS 113:9298.9303, 2016.
Laurila JP, Laukkanen MO, Joensuu H, Salmi M, Jalkanen S. Leukocyte trafficking is not affected by multikinase inhibitors sunitinib or sorafenib in mice. Int J Cancer 139:2270-2276, 2016.
Iftakhar-E-Khuda I, Fair-Mäkelä R, Kukkonen-Macchi A, Elima K, Karikoski M, Rantakari P, Miyasaka M, Salmi M, Jalkanen S. Gene-expression profiling of different arms of lymphatic vasculature identifies candidates for manipulation of cell traffic. PNAS 113:10643-10648, 2016.
Salmi M, Jalkanen S. Endothelial adhesion molecules in the lymphatic vasculature. Encyclopedia of Immunobiology, 1st edition, ed. Ratcliffe M. Academic Press, 2016.
2015
Weston CJ, Shepherd EL, Claridge LC, Rantakari P, Curbishley SM, Tomlinson JW, Hubscher SG, Reynolds GM, Aalto K, Anstee QM, Jalkanen S, Salmi M, Smith DJ, Day CP, Adams DH. Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis. Journal of Clinical Investigation. 125:501-20, 2015.
Jalkanen J, Yegutkin GG, Hollmén M, Aalto K, Kiviniemi, T, Salomaa V, Jalkanen S, Harri Hakovirta H. Aberrant circulating levels of purinergic signaling markers are associated with several key aspects of peripheral atherosclerosis and thrombosis. Circulation Research. 116:1206-15, 2015.
Johansson J, Tabor V, Wikell A, Jalkanen S, Fuxe J. TGF-β1-induced epithelial-Mesenchymal transition promotes monocyte/macrophage properties in breast cancer cells. Frontiers in Oncology 5:3. doi: 10.3389/fonc.2015.00003. eCollection 2015.
Rantakari P, Auvinen K, Valtonen J, Karikoski M, Gerke H, Jäppinen J, IIftakhar-E-Khuda I, Keuschnigg J, Miyasaka M, Elima K, Jalkanen S, Salmi M. Plvap controls the entry of antigens to conduits and lymphocyte transmigration to parenchyma in the lymphatic sinus of lymph nodes. Nature Immunology. 16:386-96, 2015.
Ritchie SC, Würtz P, Nath AP, Abraham G, Havulinna AS, Fearnley LG, Sarin A-P, Kangas AJ, Soininen P, Aalto K, Seppälä I, Raitoharju E, Salmi M, Maksimow M, Männistö S, Kähönen M, Juonala M, Ripatti S, Lehtimäki T, Jalkanen S, Perola M, Raitakari O, Salomaa V, Ala-Korpela M, Kettunen J, Inouye M. The biomarker GlycA is associated with chronic inflammation and predicts long-term risk of severe infection. Cell Systems. 1(4):293-301, 2015.
Hollmén M, Karaman S, Schwager S, Lisibach A, Christiansen AJ, Maksimow M, Varga Z, Jalkanen S, Detmar M. G-CSF-regulates macrophage phenotype and associates with poor overall survival in human triple-negative breast cancer. OncoImmunology. doi: 10.1080/2162402X.2015.1115177, 2015.
Salmi M, Adams DH, Trivedi P, Hänninen A, Jalkanen S. Systematic manifestations of mucosal diseases: trafficking of gut immune cells to joint, liver and pancreas. In Mucosal Immunology, 4th edition, eds. Mestecky J, Strober W, Russel MW, Kelsall BL, Cheroutre H, Lambrecht BN. Academic Press, pp 1749-1758, 2015.
Jalkanen S, Salmi M, Jalkanen M, Maksimow M. Biomarker for monitoring development of diseases and assessing the efficacy of therapies. (US patent 8975 081, 2015)
2014
Li XG, Helariutta K, Roivainen A, Jalkanen S, Knuuti J, Airaksinen AJ. Using 5-deoxy-5-[18F]fluororibose to glycosylate peptides for positron emission tomography. Nature Protocols. 9: 138-145, 2014.
Bellingan G, Maksimow M, Howell DC, Stotz M, Beale R, Beatty M, Walsh T, Binning A, Davidson A, Kuper M, Shah S, Cooper J, Waris M, Yegutkin GG, Jalkanen J, Salmi M, Piippo I, Jalkanen M, Montgomery M, Jalkanen S. The impact of intravenous interferon-beta-1a (FP-1201) on lung CD73 expression in vitro, and on acute lung injury mortality in an open-label study. The Lancet Respiratory Medicine. Online 2:98-107, 2014.
Schulz O, Ugur M, Friedrichsen M, Radulovic K, Niess JH, Jalkanen S, Krueger A, Pabst O. Hypertrophy of infected Peyer’s patches arises from global, interferon-receptor, and CD69-independent shutdown of lymphocyte egress. Mucosal Immunology. 7:892–904, 2014.
Esser C, Bachmann A, Kuhn D, Schuldt K, Forster B, Thiel M, May J, Koch-Nolte F, Yanez-Mo M, Sanchez-Madrid F, Schinkel AH, Jalkanen S, Craig AG, Bruchhaus I, Horstmann RD. Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes. Cell Microbiology. 6:701–708, 2014.
Aalto K, Havulinna AS, Jalkanen S, Salomaa V, Salmi M. Soluble. vascular adhesion protein-1 predicts incident major adverse cardiovascular events and improves reclassification in a finnish prospective cohort study. Circulation: Cardiovascular Genetics. 7:529-35, 2014.
Lim ET, Wurtz P, Havulinna AS, Palta P, Tukiainen T, Rehnstrom K, Esko T, Magi R, Inouye M, Lappalainen T, Chan Y, Salem RM, Lek M, Flannick J, Sim X, Manning A, Ladenvall C, Bumpstead S, Hamalainen E, Aalto K, Maksimow M, Salmi M, Blankenberg S, Ardissino D, Shah S, Horne B, McPherson R, Hovingh GK, Reilly MP, Watkins H, Goel A, Farrall M, Girelli D, Reiner AP, Stitziel NO, Kathiresan S, Gabriel S, Barrett JC, Lehtimaki T, Laakso M, Groop L, Kaprio J, Perola M, McCarthy MI, Boehnke M, Altshuler DM, Lindgren CM, Hirschhorn JN, Metspalu A, Freimer NB, Zeller T, Jalkanen S, Koskinen S, Raitakari O, Durbin R, MacArthur DG, Salomaa V, Ripatti S, Daly MJ, Palotie A. Sequencing Initiative Suomi (SISu) Project. Distribution and medical impact of loss-of-function variants in the Finnish founder population. PLoS Genetics. 10(7):e1004494.
Auvinen K, Jalkanen S, Salmi M. Expression and function of endothelial selectins during human development. Immunology. 143:406-415, 2014.
Maksimow M, Kyhälä L, Nieminen A, Kylänpää L, Aalto K, Elima K, Mentula P, Lehti M, Puolakkainen P, Yegutkin GG, Jalkanen S, Repo H, Salmi M. Early prediction of persistent organ failure by soluble CD73 in patients with acute pancreatitis. Critical Care Medicine. 42, 2556-2564, 2014.
Metsola J, Maksimow M, Ojaniemi M, Metsola H, Marttila-Ichihara F, Vuolteenaho R, Yegutkin GG, Salmi M, Hallman M, Jalkanen S. Postnatal development and LPS-responsiveness of pulmonary adenosine receptor expression and of adenosine-metabolizing enzymes in mice. Pediatric Research. 76: 515-521, 2014.
Dunkel J, Aguilar-Pimentel JA, Ollert M, Fuchs H, Gailus-Durner V, de Angelis MH, Jalkanen S, Salmi M, Veres TZ. Endothelial amine oxidase aoc3 transiently contributes to adaptive immune responses in the airways. European Journal of Immunology. 44:3232-3239, 2014.
Virtanen SS, Kukkonen-Macchi A, Vainio M, Elima K, Harkonen PL, Jalkanen S, Yegutkin GG. Adenosine inhibits tumor cell invasion via receptor-independent mechanisms. Molecular Cancer Research. 2:1863-1874, 2014.
Kelkka T, Kienhöfer D, Hoffmann M, Linja M, Wing K, Sareila O, Hultqvist M, Laajala E, Chen Z, Vasconcelos J, Neves E, Guedes M, Marques L, Krönke G, Helminen M, Kainulainen L, Olofsson P, Jalkanen S, Lahesmaa R, Souto-Carneiro MM, Holmdahl R. Reactive oxygen species deficiency induces autoimmunity with type 1 interferon signature. Antioxidants & Redox Signaling. 21: 2231-2245, 2014.
Karikoski M, Marttila-Ichihara F, Elima K, Rantakari P, Hollmen MK, Kelkka T, Gerke H, Huovinen V, Irjala H, Holmdahl R, Salmi M, Jalkanen S. Clever-1/stabilin-1 controls cancer growth and metastasis. Clinical Cancer Research. 20:6452-6464, 2014.
Yegutkin GG, Auvinen K, Karikoski M, Rantakari P, Gerke H, Elima K, Maksimow M, Quintero IB, Vihko P, Salmi M, Jalkanen S. Consequences of the lack of CD73 and prostatic acid phosphatase in the lymphoid organs. Mediators of Inflammation. 2014 014:485743. doi: 10.1155/2014/485743.
Ahtinen H, Kulkova J, Lindholm L, Eerola E, Hakanen AJ, Moritz N, Söderström M, Saanijoki T, Jalkanen S, Roivainen A, Aro HT. (68)Ga-DOTA-Siglec-9 PET/CT imaging of peri-implant tissue responses and staphylococcal infections. EJNMMI Research. 2014 Aug 8;4:45. doi: 10.1186/s13550-014-0045-3. eCollection 2014.
Jalkanen S, Salmi M, Jalkanen M. Cell and therapeutical and diagnostical methods based thereon. (US patent 8722045, 2014)
Salmi M, Jalkanen S. Ectoenzymes in leukocyte migration and their therapeutic potential. Seminars in Immunopathology. 36:163-76, 2014.